Dr Qinguo Zheng

Teaching Activity on the MPharm Programme

PH1405 (Module coordinator): Chromatographic drug analysis, orbitals and bondings, nomenclature and stereochemistry,
practical applications of pharmaceutical analysis.
PH3602: Gene therapy
PH3605: Chromatographic drug analysis.

Career History

• 1998-date Lecturer in Medicinal Chemistry, Aston University.
• 1997-98 Post-doctoral Research Fellow, MRC Toxicology Unit, University of Leicester.
• 1995-96 Post-doctoral Research Assistant, UCL.
• 1991-95 PhD Student/Research Assistant, UCL.
• 1990-91 Research Assistant, UCL.
• 1987-90 Lecturer, Zhejiang University, Zhejiang, China.
• 1984-87 Zhejiang University, Zhejiang, China, MSc in organic chemistry.
• 1978-82. Zhejiang University, Zhejiang, China, BSc in chemistry.

Research Interests

• Development of novel methodologies for synthesis of modified nucleic acids and peptide nucleic acids, and their use as potential antisense therapeutic agents.
• Oxidative DNA damage.
• Therapeutic natural products and their derivatives.
• Development of novel reagents for organic synthesis.

Selected Recent Publications

R. Guo and Q Zheng (2005)

Chemical Synthesis of oligonucleotides containing (M + 4) guanine

Nucleosides, Nucleotides, and Nucleic Acids 24 (5-7) 1081 – 1083

Z-G. Le, Z-C. Chen, Y. Hu, Q. Zheng (2005)

Organic reactions in ionic liquids: Ionic liquid-promoted efficient synthesis of N-alkyl and N-arylphthalimides.

JOURNAL OF HETEROCYCLIC CHEMISTRY 42 (4) 735-737

Y. Hu, Z-C. Chen, Z-G. Le, Q, Zheng (2004)

Organic reactions in ionic liquids: Ionic liquid promoted Knoevenagel condensation of aromatic aldehydes with (2-thio)barbituric acid.

SYNTHETIC COMMUNICATIONS 34 4521-4529

Z-G. Le, Z-C. Chen, Y. Hu, Q. Zheng (2004)

[bmim]Br(3)as a new reagent for regioselective monobromination of arylamines under solvent-free conditions.

SYNTHESIS-STUTTGART 17 2809-2812

Y. Hu, Z-C. Chen, Z-G. Le, Q. Zheng (2004)

Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate

Synthetic Communications 34 3801-3806

Z-G. Le, Z-C. Chen, Y. Hu, Q. Zheng (2004).

Organic reactions in ionic liquids: A simple and highlyregioselective N-substitution of pyrrole.

SYNTHESIS-STUTTGART 1951-1954

Y. Hu, Z-C. Chen, Z-G. Le, Q. Zheng (2004)

N-alkylation of N-monosubstituted sulfonamides in ionic liquids.

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL 347-351

Y. Hu, Z-C. Chen, Z-G. Le, Q. Zheng (2004)

Organic reactions in ionic liquids: An efficient method for selective S-alkylation of 2-mercaptobenzothia(xa)zole with alkyl halides.

SYNTHETIC COMMUNICATIONS 2039-2046

Z. G. Le, Z.-C. Chen, Y. Hu, Q. Zheng (2004)

Organic reactions in ionic liquids: Ionic liquid-promoted efficient synthesis of N-alkyl and N-arylimides.

Synthesis-Stuttgart 995-998

Z. G. Le, Z.-C. Chen, Y. Hu, Q. Zheng (2004)

Organic reactions in ionic liquids: A simple highly regioselective or regiospecific substitutions of benzotriazole

Heterocycles 63 1077-1081

Z-G. Le, Z-C. Chen, Y. Hu, Q. Zheng (2004)

Organic reactions in ionic liquids: N-alkylation of phthalimide and several nitrogen heterocycles.

Synthesis -Stuttgart 2 208-212

Z. Liu, Z-C. Chen, Q. Zheng (2004)

Organic reactions in ionic liquids: Ionic liquid-accelerated nucleophilic substitution reaction of alpha-tosyloxyketones with potassium salts of aromatic acids.

Synthesis -Stuttgart 1 33-36

Zheng, Q., Wang, Y., Lattmann,E. (2003)
Introduction of structural diversity into oligonucleotides containing 6-thioguanine via on-column conjugation.
Tetrahedron, 59, 1925 -1932.

Wang, Y., Lattmann, E., Zheng, Q. (2003)
Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis.
Nucleosides, Nucleotides & Nucleic Acids, 22, 1247-1249.

Su, C., Chen, Z-C., Zheng, Q. (2003)
Organic reaction in ionic liquids: Knoevenagel condensation catalysed by ethylenendiammonium diacetate.
Synthesis, 4, 555-559.

Zheng, Q., Wang, Y., Lattmann, E. (2003)
Synthesis of S6-(2, 4-dinitrophenyl)-6-thioguanosine phosphoramidite and its incorporation into oligoribonucleotides.
Bioorganic & Medicinal Chemistry Letters 13 3141-3144

Su, C., Chen, Z.-C., Zheng, Q. (2003)
Organic reactions in ionic liquids: alkylation of Meldrum acid
Synthetic Communications 33 2817-2822

Cheng, D-P., Chen, Z.-C., Zheng, Q. (2003).
Hypervalent iodine in synthesis 90: A mild and efficient method for the iodination of pyrazoles.
Synthetic Communications 33 2671-2676