Professor Yvonne Perrie

Professor in Pharmaceutics/Drug Delivery

PG Programme Director - MSc Drug delivery/MSc Pharmaceutical Sciences

Aston Pharmacy School
School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET
UK

email: y.perrie@aston.ac.uk
Telephone: +44 (0) 121 204 3991
Fax: +44 (0) 121 359 0733

Research Convener-  Medicines Research Unit 
Strand co-ordinator and member of research strand 'Development of novel drugs, formulations and tissues to support healthy ageing' - Aston Research Centre for Healthy Ageing
Member of the Pharmacy and Biology Teaching Programmes

Career History 

Research Interests

• Formulation Engineering of Vaccines (including conventional and DNA vaccines)
• Enhancing solubility and delivery of bioactive molecules using colloid science and technology.
• Delivery of drugs, vaccines and gene therapies using liposomes, niosomes and other novel particulate systems
• Design, physicochemical characterisation and development of non-viral systems for gene delivery
• Tissue Engineering and regenerative medicine
• Enhancing learning methods in Pharmacy Education

Membership of Professional Bodies

• UK and Ireland Controlled Release Society (President; 2006-present)

• Controlled Release Society (Newsletter Editor; 2004 - present)

• Academy of Pharmaceutical Sciences (Board Director; 2000-2006. Newsletter Editor; 2002-2004)

• European Advisory Board for the Safe use of Adjuvants

• American Association of Pharmaceutical Scientists

• The Biochemical Society

• Industrial Pharmacists Group

• International Liposome Society

• The Royal Pharmaceutical Society of Great Britain

• WHO International Working Group on DNA Vaccines

Research Support

My research group gratefully acknowledge the support of: EPSRC, EU 6th Framework programme, Lipoxen Technologies Ltd, Pfizer Global Research, Astisen Ltd, Wellcome, and The Royal Society.

Recent Publications 

PAPERS: 

• Smith AM, Ingham A, Grover LM and Perrie Y (2010).
  Polymer film formulations for the preparation of enteric pharmaceutical capsules.
  Journal of Pharmacy and Pharmacology. Accepted. 
• Alhusban F, Perrie Y, Mohammed AR (2010).
  Preparation, Optimisation and Characterisation of Lyophilised Rapid Disintegrating Tablets Based on Gelatin and Saccharide.
  Curr Drug Delivery. Oct 29 [Epub ahead of Print]. 
• Malou Henriksen-Lacey, Vincent W. Bramwell, Dennis Christensen, Else-Marie Agger, Peter Andersen, Yvonne Perrie (2010).
  Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen.
  Journal of Controlled release. Oct 26 [Epub ahead of print] 
• Farahan Al Husban, Amr M. ElShaer, Jiteen H. Kansara, Alan M. Smith, Liam M. Grover, Yvonne Perrie and Afzal R. Mohammed (2010).
  Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination.
  Pharmaceutics. 2(1), 1-17. http://www.mdpi.com/1999-4923/2/1/1/pdf 
• R Kaur, R Morris, M Bencsik, A Vangala, T Rades, Y Perrie (2009)
  Development of a novel magnetic resonance imaging contrast agent for pressure measurements using lipid-coated microbubbles.
  Journal of Biomedical Nanotechnology. 5 (6), 1-9. 
• Chrisensen D, Agger EM, Andreasen LV, Kirby, DJ, Andersen P, Perrie Y (2009). Liposome-based cationic adjuvant formulations (CAF): Past, present, and future. Journal of Liposome Research. 19(1) 2-11. 
• Bhowruth V, Minnikin DE, Agger EM, Andersen P, Bramwell VW, Perrie Y, Besra GS (2009)
  Adjuvant properties of a simplified C32 monomycolyl glycerol analogue.
  Bioorg Med Chem Lett. 2009 19(7) 2029-32. 
• Hofmann, MP, Mohammed AR, Perrie Y, Gbureck U, Barralet JE* (2009)
  High Strength brushite bone cement with controlled drug releasing capabilities.
  Acta Biomaterialia  5(1):43-49. (IF 3.1).  
• Perrie, Y*, Mohammed, A.R., Kirby, D.J., McNeil, S.E. and Bramwell, V.W. (2008) Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens.
  Int. J Pharm. 364 272-280 
• Clark, S., Cross, L M., Smith, A.M., Court, P., Vipond J, Nadian, A., Hewinson R.G., Batchelor H, K.,    Perrie, Y., Williams, A., Aldwell, F.E. &. Chambers, M.A. (2008) Assessment of different formulations of oral Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccine in rodent models for immunogenicity and protection against aerosol challenge with M Bovis.
  Vaccine. 26(46): 5791-7 
• Perrie, Y*. (2008).
  Gregory Gregoriadis: Introducing liposomes to drug delivery.
  J Drug Target. 16(7):518-9. 
• Kirby, DJ, Rosenkrands, I., Agger, E-M. Andersen, P., Coombes AGA., and Perrie, Y* (2008).
  Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres.
  J. Drug Target, 16(7):543-54.
• Robert H Morris, Martin Bencsik, Nikolaus Nestlé, Petrik Galvosas, David Fairhurst, Anil Vangala, Yvonne Perrie, Glen McHale (2008).
  Robust spatially resolved pressure measurements using MRI with novel buoyant-advection free preparations of stable microbubbles in polysaccharide gels.
  J Magn Reson; 193(2) :159-67. 
• Kirby, DJ, Rosenkrands, I., Agger, E-M. Andersen, P., Coombes AGA., and Perrie, Y* (2008).
  Formulation and characterisation of biodegradable PLGA microspheres for the delivery of a novel sub-unit TB vaccine.
  J. Drug Target, 16(4):282-93. 
• Christensen D, Kirby D, Foget C, Agger EM, Andersen P, Perrie Y, Nielsen HM (2008). alpha,alpha'-trehalose 6,6'-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying.
  Biochim Biophys Acta. 2008; 1778(5):1365-1373.  
• Kirby, DJ, Rosenkrands, I., Agger, E-M. Andersen, P., Coombes AGA., and Perrie, Y* (2008).
  PLGA microspheres for the delivery of a novel subunit TB vaccine
  J. Drug Target, 2008; 26(4) 282-293.  
• Vangala, AK, R.H.Morris, RH, Bencsik, M, and Perrie, Y* (2007).
  Preparation and characterization of gas-filled liposomes: Can they improve oil recovery. J Liposome Res., 17(3):263-272.  
• Smith, AM., Shelton, RM Perrie, Y and Harris, JJ* (2007).
  An initial evaluation of gellan gum as a material for tissue engineering applications.
  J Biomater Appl, 2007. 22(3); 241-254. doi:10.1177/0885328207076522  
• *Perrie, Y., Mohammed, A.R., Vangala, A., and McNeil, S.E (2007). Environmental Scanning Electron Microscopy Studies of Liposomes and Niosomes.
  J Liposome Res. 17(1): 27-37.  
• *Perrie, Y., Kirby, DJ., Bramwell, V.W. and Mohammed, A.R (2007).
  Recent developments in particulate vaccines.
  Recent Patents on Drug Delivery & Formulation. 1, 117-129.  
• R.H.Morris, RH*, Vangala, AK, Bencsik, M, Perrie, Y (2007)
  Three dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas filled liposomes.
  Mag. Res. Imaging, 2007, 25(4) 509-512.http://dx.doi.org/10.1016/j.mri.2006.11.021  
• Smith, AM., Harris, JJ, Shelton, RM and Perrie, Y*. (2007)
  3D culture of bone-derived cells immobilized in alginate following light-triggered gelation.
  J. Control. Release.  94-101. http://dx.doi.org/10.1016/j.jconrel.2007.01.011  
• Vangala, A., Bramwell, V.W., McNeil, E, Christensen, D., Agger, E-M., and Perrie, Y*. (2007)
  Comparison of vesicle based antigen delivery systems for delivery of hepatitis B surface antigen.
  J. Control. Release. 119(1):102-110. http://dx.doi.org/10.1016/j.jconrel.2007.01.010  
• Mohammed, AR., Coombes, AGA., and *Perrie, Y (2007)
  Amino Acids as Cryoprotectants for Liposomal delivery systems.
  Euro J Pharm Sci, 406-413. http://dx.doi.org/10.1016/j.ejps.2007.01.001  
• Mohammed, A.R., Bramwell, V.W., Coombes, A.G.A., *Perrie, Y (2006). Lyophilisation and sterilisation of liposomal vaccines to produce stable and sterile products.
  Methods, 40: 30-38. 
• Vangala. A.K., Kirby, D., Rosenkrands, I., Agger, E-M., Andersen, P. and. *Perrie, Y (2006)
  A comparative study of cationic liposomes and niosome-based adjuvant systems for protein subunit vaccines: Characterisation, Environmental Scanning Electron Microscopy analysis and immunisation studies.
  J. Pharm Pharmacol, 58:787-799.
• Bramwell V.W. & Perrie, Y* (2006).
  Particulate delivery systems for vaccines: What can we expect?
  J. Pharm Pharmacol, 58:717-28. 
• McNeil, S.E. and *Perrie, Y (2006).
  Gene Delivery using cationic lipids.
  Expert Opinion in Therapeutic Patents. 16(10):1371-1382. 
•  Chang, H-I., Perrie, Y. and *Coombes, A.G.A (2006).
  Delivery of the antibiotic gentamicin sulphate from precipitation cast matrices of polycaprolactone.
  J. Control. Release, 110:414-421 
• Gorst, N.J.S.,  Perrie, Y., Gbureck, U.,  Hutton, A.L., Hofmann, M.P., Grover L.M.,  and BarraletJ.E (2006).
  Effect of fibre reinforcement on the mechanical properties of brushite cement.
  Acta Biomater, 2(1):95-102.  
• Davidsen, J., Rosenkrands, I., Christensen, D., Vangala, A., Kirby, D., Perrie, Y., Agger, E-M., *Andersen, P (2005).
  Characterization of cationic liposomes based on dimethyl dioctadecyl ammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6‘-dibehenate) - a novel adjuvant inducing both strong CMI and antibody responses.
  Biochim Biophys Acta, 1718, 22-31.  
• Bramwell, V.W. & *Perrie, Y (2005)
  The rational design of vaccines.
  Drug Discov Today, 2005, 10 (22) 1527-1534. 
• Chang, H-I., Williamson, M.R., Perrie, Y. and *Coombes, A.G.A. (2005)
  Precipitation casting of Drug-loaded microporous PCL Matrices: Incorporation of Progesterone by co-dissolution. 
  J. Control. Release,106,(3): 263-272. 
• Bramwell, V.W. & *Perrie, Y (2005).
  Particulate delivery systems for vaccines.
  Crit Rev Ther Drug Carrier Syst, 22(2):151-214.  
• Mohammed, A.R., Coombes, A.G.A, Fitzgerald, M., and *Perrie, Y (2004)
  Liposome formulation of poorly water soluble drugs: Optimisation of drug loading and ESEM analysis of stability.
  Int. J. Pharm, 285, 23-34.
• *Perrie, Y., Barralet, J.E., McNeil, S. and Vangala. A.K (2004)
  Liposome and niosome mediated DNA vaccination via the subcutaneous route.
  Int. J. Pharm, 284, 31-41.
• *Perrie, Y., McNeil, S. and Vangala. A.K (2003).
  Liposome-mediated DNA immunisation via the subcutaneous route.
  J. Drug Targeting, 11, 555-563.
•  Perrie, Y. Obrenovic, M, McCarthy, D. and Gregoriadis, G (2002).
  Liposome-mediated DNA vaccination via the oral route.
  J Liposome Res, 12,185-197
• Perrie, Y., Frederik P.M., and Gregoriadis, G (2001).
  Liposome-mediated immunisation: The effect of vesicle composition.
  Vaccine, 19, 3301-3310
• Perrie, Y. and Gregoriadis, G (2000).
  Liposome-entrapped plasmid DNA: Characterisation Studies.
  Biochim Biophys Acta, 1475,125-132.
• Gregoriadis, G., McCormack, B., Obrenovic, M., Saffie, R., Zadi, B. and Perrie, Y (1999).
  Vaccine entrapment in Liposomes.
  Methods, 19,156-162.

JOURNALS (Professional - other)  

• Perrie, Y*, Smith, AM., Harris, JJ, and Shelton, RM (2006).
  A new trick for an old delivery system.
  Pharm J.  277: 780.  
• Perrie, Y (2005)
  How Pharmaceutical Scientists are going prospecting for black gold.
  Pharm J.  275(1): 809.  

PATENTS 

• Smith, AM. & Perrie Y. Enteric Pharmaceutical Capsules.
  Filed 26/03/08 GB/29.3.07/GBA  0706178. PCT/GB2008001038

• Perrie, Y. Griffiths, H.R., Phillips, D.C. Ceramide derivatives for the treatment of inflammation. 2004. Patent number W02004064823. (Published 05/08/2004)

• Gregoriadis, G. and Perrie, Y. Liposome-entrapped DNA oral vaccines. 2001 Patent number WO0124773, (Published 12/04/2001)
  

 REVIEWS (Invited)

•  Bramwell, V.W. & Perrie, Y (2007).
  Natural and synthetic additives.
  European Biopharmaceutical Review. Spring: 78-83.

• Perrie, Y (2005)
  Liposome delivery of sparingly soluble drugs. 
  European Biopharmaceutical Review. Autumn: 90-97.

• Mohammed, A.R. & *Perrie, Y. (2005)
  Liposome solutions for sparingly soluble drugs.
  Drug Delivery Companies Report. Autumn/Winter, 2005, 9-11. 

 BOOK CHAPTERS

• Gregoriadis G, and Perrie Y. (2010).
  Liposomes. In Encyclopaedia of Life Sciences.
  John Wiley & Sons, UK. In press.  
• Yvonne Perrie, Habib Ali, Daniel J Kirby, Afzal U.R. Mohammed, Sarah E McNeil and Anil Vangala (2010).
  Environmental Scanning Electron Microscope Imaging of Vesicle Systems. In Liposomes, Methods in Molecular Biology, vol. 606, p319-331.
  Humana Press, Springer Science.  
• ChristensenD, KorsholmK, WoodKJ, Mohammed AM, Bramwell VW, Agger EM and Perrie Y (2009)
  Liposomes as adjuvant systems for parenteral delivery of vaccines.
  In Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines.  
• Gregoriadis, G., McCormack, B., Perrie, Y., Bacon, A., Caparros-Wanderley, W. and Zadi, B.(2003).
  Liposome-based DNA vaccines: Procedures for entrapment. In Liposomes - A practical approach, 2nd ed., V.P. Torchilin, and V. Weissig eds.
  Oxford University Press. Practical Approach Series.  
• Perrie, Y. and Gregoriadis, G. (2000)
  Liposomal DNA Vaccines: Structural Characteristics. In Gregoriadis and McCormack, (Ed.) Targeting of Drugs, Targeting of Drugs: Strategies for Gene Constructs and Delivery. p. 102-111, Amsterdam, The Netherlands: IOS Press.  
• Gregoriadis, G., McCormack, B., Obrenovic, M., Perrie, Y. and Yang, J-C. (2000) Genetic Vaccines: A Role for Liposomes. In Gregoriadis and McCormack, (Ed.) Targeting of Drugs, Targeting of Drugs: Strategies for Gene Constructs and Delivery, p. 92-110. Amsterdam, The Netherlands: IOS Press.  
• Gregoriadis, G., McCormack, B., Obrenovic, M., Perrie, Y. and Saffie, R. (2000)
  Liposomes As Immunological Adjuvants and Vaccine Carriers. In O'Hagen D.T. (Ed). Methods in Molecular Medicine, vol 42, Vaccine Adjuvants: Preparation Methods and Research Protocols. p. 137-150. Totowa, NJ: Humana Press Inc  
• Gregoriadis, G., McCormack, B., Obrenovic, M., and Perrie, Y. (1999)
  Entrapment of Plasmid DNA Vaccines into Liposomes by Dehydration/Rehydration.
  In Lowrie, D.B. and Whalen, R. (Eds.) Methods in Molecular Medicine, vol 9, DNA Vaccines: Methods and Protocols. p. 305-312. Totowa, NJ: Humana Press Inc.  
• Gregoriadis, G., McCormack, B., Morrison (Perrie), Y., Saffie, R. and Zadi, B. (1998) Liposomes in drug targeting.
  In: Cellis, J.E. (Ed.) Cell biology: A laboratory handbook, 2nd edn. p. 131-140. New York: Academic Press.  
• Gregoriadis, G., McCormack, B., Perrie, Y. and Saffie, R. (1998)
  DNA Vaccination: A role for liposomes. In: Lasic, D.D. and Papahadjopoulos, D. (Eds.) Medical applications of liposomes, p. 61-73. New York: Elsevier Science 
• Gregoriadis, G., McCormack, B., Perrie, Y. and Saffie, R. (1998)
  Liposome-mediated DNA vaccination. In: Janoff, A. (Ed.) Liposomes: Rational Design, p. 205-218. New York: Marcel Dekker, Inc  

BOOKS

FASTtrack Pharmaceutics – Drug Delivery and Targeting (2009). 
Yvonne Perrie and Thomas Rades.
London: Pharmaceutical Press.  

PUBLISHED ARTICLES (Education): 

Perrie, Y. Influenza symptoms and treatments.
Pharm J. 2006, 277: 399:402. 

Perrie, Y. Vaccines: an overview and update.
Pharm J. 2006. 276(7388): 209-212.  

Perrie, Y. Optimisation of assessment and feedback in large-group practicals.
J Pharm Pharmacol. 2004, 56, S-63. 

Perrie, Y. Turning a dull lecture into an unforgettable learning experience.
Pharm. J. 2003a, 270, 754-6. 

Perrie, Y. Virtual Learning Environments.
Pharm. J. 2003b, 270, 794-5. 

Perrie, Y. Choosing an Assessment Strategy.
Pharm. J. 2003c, 271, 86-88. 

Wittingham, C and Perrie, Y. Application of “Exocharmic” Demonstrations in Pharmaceutics Lectures.
Pharmacy Education, 2002, 2,157-8.

Dr Yvonne Perrie / Aston University / last updated January 2010