Dr Eric Lattmann

Career History

• 1997-date Lecturer in Medicinal Chemistry, Aston University
• 1995-96 Research Fellow, University of Aberdeen
• 1993-95 PhD, Organic Chemistry (summa cum laude), University of Hannover
• 1988-92 MSc, Chemistry, University of Hannover

Research Interests

• Design and synthesis of new drugs from combinatorial libraries and natural products
• Combinatorial synthesis and automated synthesis
• Chemistry and biology of Cholecystokinin antagonists
• Synthesis and evaluation of Kawa lactones and Hyperforin based anti-depressants
• Snake bite antidotes
• Novel analgesic drugs

Recent Publications

• Eric Lattmann, Harjit Singh, Yodchai Boonprakob, Pornthip Lattmann, Jintana Sattayasai (2006) Synthesis and evaluation of N-(3oxo-2,3-dihydro-1Hpyrazol-4-yl)-1H-indole-carboxamide as cholecystokinin antagonists, J. Pharm. Pharm. 2006, 58, 1-9
• Eric Lattmann, Isidro Merino, Simon Dunn, Bushra Parveen, Pornthip Lattmann, David C. Billington, Yodchai Bunprakob, Jintana Sattayasai (2006)
  Novel 5-HT-7 Ligands as Antidepressants: Automated Synthesis of N-Substituted-N-[1-Methyl-3-(4-Methylpiperidin-1yl)propyl-]Arylsulfonamides,
  Lett. Drug Design Discovery, 3, 625-630
• Michael Offel, Pornthip Lattmann, Harjit Singh, David C. Billington, Yodchai Bunprakob, Jintana Sattayasai, Eric Lattmann (2006)
  Synthesis of substituted 3-anilino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepinones and their evaluation as cholecystokinin ligands
  Archiv der Pharmazie - Chemistry in Life Science, 339, 163-173
• Eric Lattmann, Nison Sattayasai, Carl H. Schwalbe, Suwanna Niamsanit, David C. Billington, Pornthip Lattmann, Christopher A. Langley, Harjit Singh and Simon Dunn (2006)
  Novel Anti-bacterials against MRSA: Synthesis of Focussed Combinatorial Libraries of Tri-substituted 2(5H)-furanones
  Current Drug Discovery Technologies, 3, 125-134
• Lattmann, E., Sattayasai, J., Boonprakob, J., Lattmann, P., Singh, H. (2005)
  Synthesis and evaluation of N-(5-methyl-3-oxo1,2-diphenyl-2,3-dihydro-1H-pyrazol-4yl)-N-phenylureas as Cholecystokinin antagonists
  Drug Res. / Arzneimittelforschung 55, 251-258
• Eric Lattmann, Simon Dunn, Suwanna Niamsanit and Nison Sattayasai (2005)
  Synthesis and antibacterial activities of 5-hydroxy-4-amino-2(5H)-furanones
  Bioorganic & Medicinal Chemistry Letters 15, 919-921
• Eric Lattmann, Simon Dunn, Suwanna Niamsanit and Nison Sattayasai (2005)
  Antibacterial pyrrols,
  UK patent application 0520368.2, 06-Oct-2005, Aston University
• Lattmann, E., Kinchington, D., Dunn, S., Singh, H., Ayuko, W.O., Tisdale, M.J. (2004)
  Cytotoxicity of 3,4-dihalogenated 2(5H)-furanones
  J. Pharm. Pharm. 2004, 55, 1163-1170
• 3-substituted anilino-1,4-benzodiazepines as selective non-peptide CCK-A Cholecystokinin ligands. (2003)
  Eric Lattmann, Michael Offel and Harjit Singh, Aston University,
  UK-patent No. 312365, 30th May 2003
• Ureido- and amido- pyrazoline derivatives as non-peptide Cholecystokinin ligands. (2003)
  Eric Lattmann, Pornthip Lattmann, Harjit Singh, Aston University,
  UK-patent No. 312368.4, 30th May 2003
• 4-Amino-5-substituted 2(5H)-furanones as non-peptide Cholecystokinin ligands. (2003)
  Eric Lattmann, Pornthip Lattmann and Harjit Singh, Aston University,
  UK-patent No. 312360.1, 30th May 2003
• Bicyclic furanones as Antibiotics: Synthesis of 2-oxa-6-azabicyclo[3.1.0]hex-4-en-3-ones and their evaluation as novel antibiotics (2003)
  Aston University, Eric Lattmann, Isidro Merino,
  UK-patent No. 303874.2, 20th February 2003
• Novel Sulfonamides as 5HT-7 ligands. (2003)
  Eric Lattmann, Isidro Merino,
  UK-Application No. 316128.8, 10th July 2003
• Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis. (2003)
  Wang, Y., Lattmann, E., Zheng, Q.
  Nucleosides, Nucleotides & Nucleic Acids 2003, 22, 1247-1249.
• Introduction of structural diversity into ligonucleotides containing 6-thioguanine via on-column conjugation. (2003)
  Zheng, Q., Wang, Y., Lattmann, E.;
  Tetrahedron 2003, 59, 1925-1932
• Synthesis of S6-(2, 4-initrophenyl)-6-thioguanosine phosphoramidite and its incorporation into oligoribonucleotides. (2003)
  Zheng, Q., Wang, Y., Lattmann, E.;
  Bioorganic & Medicinal Chemistry Letters 2003, 13, 3141-3144
• Synthesis and Evaluation of 5-Arylated 2(5H)-Furanones and 2-Arylated Pyridazin-3(2H)-ones as Anticancer Agents. (2003)
  Eric Lattmann, Washington O. Ayuko, Derek Kinchinaton, Christopher A. Langley, Leila Karimi, Harjit Singh and Mike J. Tisdale;
  J. Pharm. Pharm. 2003, 55, 1259-1265
• Review article: From CNS-Drugs to Anti-Neoplastic Agents: Cholecystokinin (CCK)-Antagonists as Modern Anti-Cancer Agents (2003)
  Eric Lattmann and Pornthip Lattmann; Science (KKU) 2003, 31, 178-193
• Lattmann, E., Billington, D.C., Poyner, D.R., Arayarat, P., Howitt, S.B., Lawrence, S. and Offel, M. (2002)
  Combinatorial solid phase synthesis of multiply-substituted 1,4-benzodiazepines and affinity studies on the CCK2 receptor (Part 1).
  Drug Design and Discovery, 18, 9-21.
• Lattmann, E., Sattayasai, J., Billington, D.C., Poyner, D.R., Puapairoj, P., Tiamkao, S., Airarat, W., Singh, H. and Offel, M. (2002)
  Synthesis and evaluation of N₁-substituted-3-propyl –1,4-benzodiazepine-2-ones as Cholecystokinin (CCK₂)-receptor ligands.
  J. Pharm. Pharm. 54, 827-834.
• Lattmann, E., Offel, M., Poyner D.R. and Arayarat, P. (2002)
  Synthesis and affinity of 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines as selective Cholecystokinin-(CCK)-ligands.
  Science (KKU), 30, 114-125.
• Lattmann, E., Kinchington, D., Singh, H., Merino, I., Begum, A., Ayuko W. and Tisdale, M.J. (2001)
  Synthesis of simple and bis-cyclic 3,4-dihalogenated 2(5H)-furanones and their evaluation as novel cytotoxic agents.
  Pharm. Pharm. Lett. 11, 5-8.
• Lattmann, E., Ayuko, W., and Tisdale, M.J. (2001)
  Methacrylic acid derivatives. Antiproliferative agents.
  No. 0106137.3; UK patent toEPX Research Ltd.
• Lattmann, E., Billington, D.C., Poyner, D.R., Howitt, S.B. and Offel M. (2001)
  Synthesis and evaluation of Asperlicin analogues as non-peptidal Cholecystokinin-antagonists.
  Drug Design and Discovery, 17, 219-230.
• Arayarat, P., Singh, H. and Lattmann, E. (2001)
  Solid phase synthesis of substituted 4-amino-5-hydroxy-2(5H)-furanones.
  Science Asia, 27, 121-125.
• Lattmann, E., Billington, D.C., Poyner, D.R., Howitt, S.B. and Offel, M. (2001)
  Solid phase synthesis of 3-alkylated 1,4-benzodiazepines as non-peptidal Cholecystokinin antagonists.
  Pharm. Pharm. Lett. 11, 5-8.
• Plater, M.J., Kemp, S. and Lattmann, E. (2000)
  Heterocyclic free radicals. Part 1. 4,5-Diazofluoren derivatives of Koelsch free radical: an EPR and metal-ion complexation study
  J. Chem. Soc., Perkin Trans. 1, 971-979.
• Lattmann,E., Arayarat, P. and Singh, H. (2000)
  Small organic molecules as cholecystokinin antagonists.
  Science (KKU), 28, 288-299.
• Lattmann, E., Begum, A. and Plater, M. J. (1999)
  Synthesis and design of stable, water soluble radicals as potential anti-cancer agents.
  Drug Design and Discovery, 16, 195-201.
• Lattmann, E., Billington, D.C. and Langley, C.A. (1999)
  Synthesis of combinatorial libraries of 3,4,5-substitutes 2(5H)-furanones. Part one: Construction of a sub-library of halogenated 5-alkoxy-2(5H)-furanones
  Drug Design and Discovery, 16, 237-242.
• Lattmann, E., Billington, D.C. and Langley, C. A. (1999)
  Synthesis of combinatorial libraries of 3,4,5-substitutes 2(5H)-furanones. Part two: Construction of a library of 4-amino-5-alkoxy-2(5H)-furanones.
  Drug Design and Discovery, 16, 243-250.
• Lattmann, E., Billington, D. C., Arayarat, P., Singh H. and Offel, M. (1999)
  Preparation of a novel resin derived from an ion-exchange resin and its evaluation in peptide- and benzodiazepine synthesis.
  ScienceAsia, 25, 107-112.
• Lattmann, E., Arayarat, P. (1999)
  Process development: Synthesis of benzofuranyl-imidazoline (2-BFI) as selective and highly potent I-2 ligand with potential antidepressant activity.
  Science (KKU), 27, 32-37.
• Martin, I.L. and Lattmann, E. (1999)
  Benzodiazepine recognition site ligands and GABA_A receptors.
  Exp. Opin. Ther. Patents, 9, 1347-1358.
• Coombs, J., Lattmann, E., Hoffmann, H. M. R. (1998)
  Total synthesis of Manoalide
  Synthesis, 1367 – 1371.
• Ayuko, W. O., Lattmann, E. (1998)
  Butenolide derivatives as anti-cancer agents
  WO9952888 ( to Kanvir Research LTD. )
• Lattmann, E. (1998)
  Stable, water soluble free radicals as anti-cancer and antibiotic agents.
  Pat. Appl. Nr. 9826981.4, UK-patent
• Lattmann, E., Hoffmann, H. M. R. (1996)
  From tetronic acid and furfural to C(4)-halogenated, vinylated and formylated furan-2(5H)-ones and their 5-alkoxy derivatives.
  Synthesis, 155 - 163.
• Hoffmann, H. M. R., Gerlach, K., Lattmann, E. (1996)
  New bicyclic conjugates of three- and five-membered heterocycles with 5-alkoxyfuran-2(5H)-ones (4-alkoxy-²-butenolides).
  Synthesis, 164 – 170.
• Lattmann, E., Coombs, J., Hoffmann, H. M. R. (1996)
  Pyranofuranones via lewis acid mediated hetero-Diels-Alder reactions of 4-furan-2(5H)-ones : A convergent route to the Manoalide substructure.
  Synthesis. 171 - 177.

Dr Eric Lattmann / Aston University / last updated December 2006