Particular aspects covered in the course include those detailed in the videos below. By clicking on the images you can watch the lectures which were recorded during a recent visit to a local high school in Birmingham.
Statistical Analysis in Microbiology
This book is aimed primarily at microbiologists who are undertaking research, and who require a basic knowledge of statistics to analyse their experimental data. Computer software employing a wide range of data analysis methods is widely available to experimental scientists. The availability of this software, however, makes it even more essential that microbiologists understand the basic principles of statistics.
Statistical analysis of data can be complex with many different methods of approach, each of which applies in a particular experimental circumstance. In addition, most statistical software commercially available is complex and difficult to use. Hence, it is easy to apply an incorrect statistical method to data and to draw the wrong conclusions from an experiment.
The purpose of this book is an attempt to present the basic logic of statistics as clearly as possible and therefore, to dispel some of the myths that often surround the subject. The book is presented as a series of 'Statnotes', many of which were originally published in the 'Microbiologist
' by the Society for Applied Microbiology
, each of which deals with various topics including the nature of variables, comparing the means of two or more groups, non-parametric statistics, analysis of variance, correlating variables, and more complex methods such as multiple linear regression and factor analysis. In each case, the relevant statistical methods are illustrated with scenarios and real experimental data drawn from experiments in microbiology. The text will incorporate a glossary of the most commonly used statistical terms and a section to aid the investigator to select the most appropriate test.
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Manuscripts (2004 - 2010)
For a full list of publications including those prior to 2004 please follow the link and search for HILTON AC in the Author field.
Tarja J Karpanen, Barbara R Conway, Tony Worthington, Anthony C Hilton, Tom SJ Elliott and Peter A Lambert (2010) Enhanced chlorhexidine skin penetration with eucalyptus oil. BMC Infectious Diseases. http://www.biomedcentral.com/1471-2334/10/278
Simon WJ Gould, Paul Cuschieri, Jess Rollason, Anthony C Hilton, Sue Easmon and Mark D Fielder (2010) The need for continued monitoring of antibiotic resistance patterns in clinical isolates of Staphylococcus aureus from London and Malta. Annals of Clinical Microbiology and Antimicrobials http://www.ann-clinmicrob.com/content/9/1/20
Lauren M. Green, Tony Worthington, Anthony C. Hilton & Peter A. Lambert (2009) Phenotypic characterisation of Clostridium difficile reveals lack of extracellular virulence factor production and significant differences in antibiogram profiles. Int J Antimicrob Agents doi:10.1016/j.ijantimicag.2009.10.018
Edward Hurrell, Eva Kucerova, Michael Loughlin, Juncal Caubilla-Barron, Anthony C Hilton, Richard Armstrong, Craig Smith, Judith Grant, Shiu Shoo and Stephen Forsythe (2009) Neonatal enteral feeding tubes as loci for colonisation by members of the Enterobacteriaceae BMC Infectious Diseases 9 (14) http://www.biomedcentral.com/1471-2334/9/146/abstract
Karpanen TJ, Worthington T, Conway BR, Hilton AC, Elliott TS, Lambert PA. (2009) Permeation of chlorhexidine from alcoholic and aqueous solutions within excised human skin. Antimicrob Agents Chemother. Jan 21. [Epub ahead of print]
Wheeldon LJ, Worthington T, Hilton AC, Elliott TS, Lambert PA. (2009) Physical and chemical factors influencing the germination of Clostridium difficile spores. J Appl Microbiol. 105(6): 2223-30.
S. W. J. Gould, J. Rollason, A. C. Hilton, P. Cuschieri, L. McAuliffe, S. L. Easmon and M. D. Fielder (2008) UK epidemic strains of meticillin-resistant Staphylococcus aureus in clinical samples from Malta J Med Microbiol ; 57: 1394-1398
Karpanen, T.J., Worthington, T., Conway, B.R., Hilton, A.C., Elliot, T.S. and Lambert, P.A.(2008) Penetration of chlorhexidine into human skin. Antimicrob. Agents.Chemother. August Epub ahead of print. [online]
Wheeldon, L.J, Worthington, T., Lambert, P.A., Hilton, A.C., Lowden, C.J., and Elliott, T.S. (2008) Antimicrobial efficacy of copper surfaces against Clostridium difficile spores.
J. Antimicrob. Chemother. June Epub ahead of print [online]
Wheeldon, L.J, Worthington, T., Hilton, A.C., Lambert, P.A., and Elliott, T.S.J. (2008)
Sporicidal activity of two disinfectants against Clostridium difficile spores.
Br. J. Nurs. 17, 316-320. [online]
Caddick, J.M., Hilton, A.C., Armstrong, R.A., Lambert, P.A. Worthington, T. and Elliott, T.S.J. (2006) Description and critical appraisal of principal components analysis (PCA) methodology applied to pulsed-field gel electrophoresis profiles of methicillin-resistant Staphylococcus aureus isolates. J. Microbiol. Meth. 65, 87-95. [online]
Casey, A.L., Worthington, T., Caddick, J.M, Hilton, A.C., Lambert, P.A. and Elliott, T.S.J. (2006) RAPD for the typing of coagulase-negative staphylococci implicated in catheter-related bloodstream infection.J. Infect. 52, 282-289. [online]
Small HE, Casey AL, Rollason J, Ball S, Hilton, A.C., Elliott TSJ (2008) The oral cavity - an overlooked site for MRSAscreening and subsequent decolonisation therapy? Journal of Infection 55 378-383 [online]
Bastin, L., Rollason, J., Hilton, A.C., Pillay, D., Corcoran, C., Elgy, J., Lambert, P., Worthington, T., De, P.,and Burrows, K. (2007) Spatial aspects of MRSA epidemiology: a case study using stochastic simulation, kernel estimation and SaTScan. Intl. J. Geograph. Inf. Sci. 21, 811-835. [online]
Caddick, J.M., Hilton, A.C., Rollason, J., Lambert, P.A., Worthington, T. and Elliott, T.S.J. (2005) Molecular analysis of methicillin-resistant Staphylococcus aureus reveals an absence of plasmid DNA in multidrug-resistant isolates. FEMS Immunol. Med. Microbiol., 44, 297-302. [online]
Braoudaki M, Hilton, A.C. (2005) Mechanisms of resistance in Salmonella enterica adapted to erythromycin, benzalkonium chloride and triclosan. Int J Antimicrob Agents. Jan;25(1):31-7. [online]
Braoudaki M, Hilton, A.C. (2004) Low level of cross-resistance between triclosan and antibiotics in Escherichia coli K-12 and E. coli O55 compared to E. coli O157.
FEMS Microbiol Lett. Jun 15;235(2):305-9. [online]
Braoudaki M, Hilton, A.C. (2004)Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents.J Clin Microbiol. Jan;42(1):73-8. [online]
K.J. Parker, D.L.Rathbone, P.A.Lambert, M.D.Coleman, A.C.Hilton, A. Worthington, D.C. Billington. (2006) Anti-Bacterial Compounds. International Patent, Application Number PCT/GB2006/000101, Filing date: 12.01.06, Priority date: 12.01.05