.

Dr Peter J. Hanson

hansonpj-1.jpg

Senior Lecturer in Biochemistry

Director of Biology and Biomedical Science Undergraduate Programmes


School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET
UK

email: p.j.hanson@aston.ac.uk
Tel: +44 (0) 121 204 3952
Fax: +44 (0) 121 204 4187

Member of the Inflammation and Infection Research Group (I&I)

Member of research strand 'Development of novel drugs, formulations and tissues to support healthy ageing' - Aston Research Centre for Healthy Ageing

Career History

Research Interests

  • The pharmacology and biochemistry of signal transduction mechanisms in the gastrointestinal tract
  • The apoptotic, proliferative and necrotic responses of gastric surface epithelial cells in culture after exposure to nitric oxide (NO), superoxide and non-steroidal antiinflammatory drugs (NSAIDs)
  • Applications of preparations of gastric and colonic epithelial cells grown on porous polycarbonate support membranes Transwells in biopharmaceutical screening
  • Effects of endotoxin (lipopolysaccharide)  on apoptosis and barrier function in gastric and colonic epithelial monolayers

Membership of Professional Bodies

  • Biochemical Society

Recent Publications

• Kavvada, K. M., Murray, J. G., Moore, V. A., Coombes, A. G. A. & Hanson. P. J. (2006)
High permeability of the anionic form restricts accumulation of indomethacin by cultured gastric surface epithelial cells exposed to low apical pH.
Eur. J. Pharmacol. 549, 41-49.

• Durkin, E., Moran, A.P., & Hanson. P.J. (2006).
Apoptosis induction in gastric mucous cells in vitro: lesser potency of Helicobacter pylori than Escherichia coli lipopolysaccharide, but positive interaction with ibuprofen.
Journal of Endotoxin Research. 12, 47-56.

• Kavvada, K. M., Murray, J. G., Moore, V. A., Coombes, A. G. A. & Hanson, P. J. (2005).
A collagen IV matrix is required for gastric epithelial cell monolayers to provide an optimal model of the stomach surface for biopharmaceutical screening.
J. Biomolecular Screening 10, 495-507.

• Ashton, M. & Hanson, P. J. (2002).
Disparate effects of non-steroidal anti-inflammatory drugs on apoptosis in gastric mucous cells: inhibition by diclofenac.
Br J. Pharmacol. 135, 407-416.

• Bersimbaev, R. I., Yugai, Y. E., Hanson, P. J. &. Tsoy I. G . (2001).
Effect of nitric oxide on apoptotic activity in the gastrointestinal tract.
Eur. J. Pharmacol. 423, 9-16.

• Potter, C. L. & Hanson, P. J. (2000).
Exogenous nitric oxide inhibits apoptosis in gastric mucous cells.
Gut, 46, 156-163.

• Johal, K. & Hanson, P. J. (2000).
Opposite effects of flurbiprofen and the nitroxybutyl ester of flurbiprofen on apoptosis in cultured gastric mucous cells.
Brit. J. Pharmacol., 130, 811-818.

• Byrne, C. R. & Hanson, P. J. (1998).
Induction of heat shock protein 72 by a nitric oxide donor in gastric mucosal cells.
European Journal of Pharmacology 353, 117-122.

• Byrne, C. R., Price, K. J., Williams, J. M., Brown, J. F., Hanson, P. J. & Whittle, B. J. R. (1997).
Nitric oxide synthase and arginase in cells isolated from the gastric mucosa.
Biochimica et Biophysica Acta, 1356, 131-139.

Dr Peter Hanson / Aston University / last updated November 18 2009