Senior Lecturer in Biochemistry School of Life and Health Sciences
Birmingham B4 7ET
Tel: +44 (0) 121 204 3952
Fax: +44 (0) 121 204 4187
Member of the Chronic & Communicable Disease Research group
Member of research strand 'Development of novel drugs, formulations and tissues to support healthy ageing' - Aston Research Centre for Healthy Ageing
Teaching Activity on the Biology/BMS Programmes
Teaching of Biochemistry at levels 4-6, Statistics at level 5, and Diseases of the Gastrointestinal Tract at level 6
Teaching Activity on the MPharm Programme
Teaching on second year pharmacology modules
- Applications of preparations of gastric and colonic epithelial cells grown on porous polycarbonate support membranes (Transwells) in biopharmaceutical screening
- Effects of endotoxin (lipopolysaccharide) on apoptosis and barrier function in gastric and colonic epithelial monolayers
- The pharmacology and biochemistry of signal transduction mechanisms in the gastrointestinal tract
Membership of Professional Bodies
Absorption and metabolism of chlorogenic acids in cultured gastric epithelial monolayers. Farrell, T. L. , Dew, T. P. , Poquet, L. , Hanson, P.
& Williamson, G. Dec-2011 In : Drug metabolism and disposition. 39
, p. 2338-2346.
Physicochemical characterisation, drug polymer dissolution and in vitro evaluation of phenacetin and phenylbutazone solid dispersions with polyethylene glycol 8000. Khan, S. , Batchelor, H.
, Hanson, P.
, Perrie, Y.
& Mohammed, A-U-R. Oct-2011 In : Journal of pharmaceutical sciences. 100
, p. 4281-4294.
Systems biology approach to study permeability of paracetamol and its solid dispersion. Khan, S. , Elshaer, A. , Rahman, A. S. , Hanson, P.
, Perrie, Y.
& Mohammed, A-U-R. Sep-2011 In : International journal of pharmaceutics. 417
, p. 272-279.
Genomic evaluation during permeability of indomethacin and its solid dispersion. Khan, S. , ElShaer, A. , Rahman, A. S. , Hanson, P. , Perrie, Y. & Mohammed, A-U-R. Sep-2011 In : Journal of drug targeting. 19, 8, p. 615-623.
Use of amino acids as counterions improves the solubility of the BCS II model drug, indomethacin. ElShaer, A. , Khan, S. , Perumal, D. , Hanson, P.
& Mohammed, A-U-R. Jul-2011 In : Current drug delivery. 8
, p. 363-372.
Paracellular permeability is increased by basal lipopolysaccharide in a primary culture of colonic epithelial cells; an effect prevented by an activator of Toll-like receptor-2. Hanson, P. J. , Moran, A. P. & Butler, K. Jun-2011 In : Innate immunity. 17, 3, p. 269-282. .
High permeability of the anionic form restricts accumulation of indomethacin by cultured gastric surface epithelial cells exposed to low apical pH. Kavvada, K. M., Murray, J. G., Moore, V. A., Coombes, A. G. A. & Hanson. P. J. (2006) Eur. J. Pharmacol. 549, 41-49.
Apoptosis induction in gastric mucous cells in vitro: lesser potency of Helicobacter pylori than Escherichia coli lipopolysaccharide, but positive interaction with ibuprofen. Durkin, E., Moran, A.P., & Hanson. P.J. (2006). Journal of Endotoxin Research. 12, 47-56.