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Dr Bill Fraser

fraserw-1.jpg

Lecturer in Medicinal Chemistry


UG Admissions Tutor - Pharmacy

Aston Pharmacy School
School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET
UK

email: w.fraser@aston.ac.uk
telephone: +44 (0) 121 204 3940

Member of the Biomedical Chemistry Research Group
Member of the Pharmacy and Biology Teaching Programmes

 

Career History

1991-date Lecturer in Medicinal Chemistry, Aston University
1989-91 Royal Society Post-doctoral Fellow, Eth, Zurich
1986-89 PhD, University of Strathclyde
1982-86 BSc Hons, Class I, Chemistry University of Strathclyde

Research Interests

  • Solid phase chemical synthesis
  • Antisense/antigene technology
  • Molecular recognition
  • Heterocyclic synthesis

Recent Publications

  • Crawford JA, Fraser W, Ramsden CA (2009) Preparation of 9-Substituted   Pyridine-Stretched Adenines and Hypoxanthine, Synthesis, 1271-1278  ISSN 0936-5214
  • Fraser W Oxatriazoles In Comprehensive Heterocyclic Chemistry III Katrizky AR, Ramsden CA, Scriven EFV, Taylor RJK Eds. Elsevier: Oxford 2008 Vol 6, pp 425-440
  • Fraser W 1,2,3-Oxadiazoles In Comprehensive Heterocyclic Chemistry III Katrizky AR, Ramsden CA, Scriven EFV, Taylor RJK Eds. Elsevier: Oxford 2008 Vol 5, pp 211-242
  • Walsh AJ, Davis ML, Fraser W (2006). Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules 11: 486-495.
  • Fraser W Alkylboron and –Silicon Compounds In Comprehensive Organic Functional Group Transformations II Katrizky AR, Taylor RJK Eds. Elsevier: Oxford 2005 Vol 2 Chapter 2.10 pp 485-530.
  • Clayton, R., Davis, M.L., Fraser, W., Li, W., and Ramsden, C.A. (2002)
    Synthesis of Pyridine-stretched 2'-Deoxynucleosides
    Synlett.     1483-1486.
  • Walsh, A.J. and Fraser, W. (2001)
    Oligonucleotide Conjugates of the Base-Labile Anticancer Drug Temodal: SLCPG-Supported Solid Phase Synthesis.
    In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 1999, ed. Epton, R., Mayflower Worldwide, Kingswinford, Ch. 30, pp 137-140.
  • Walsh, A.J. and Fraser, W. (2001)
    Replacement of Adenine by Isoguanine in Triplex-Forming DNA Oligomers is Not Destabilising.
    In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 1999, ed. Epton, R., Mayflower Worldwide, Kingswinford, Ch. 100, pp 377-378.
  • Wallis, M.P., Mahmood, N. and Fraser, W. (1999)
    Synthesis and Anti-HIV activity of C4-modified pyrimidine nucleosides.
    Farmaco     54, 83-89.
  • Groebke, K., Hunziker, J., Fraser, W., Peng, L., Diederichsen, U., Zimmermann, K., Holzner, A., Leumann C. and A Eschenmoser (1998)
    Why pentose-and not hexose- nucleic acids? Purine-purine pairing in homo-DNA series: Guanine, isoguanine, 2,6-diaminopurine and xanthine.
    Helvetica Chimica Acta     81, 375-474.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1998)
    9-(Carboxymethyl)-6-chloropurine ethyl ester.
    Acta Crystallogr.     C54, 1907-1909.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1998)
    7-(Carboxymethyl)-6-chloropurine ethyl ester.
    Acta Crystallogr.     C54, 1316-1318.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1998)
    6-Amino-9-(carboxymethyl)-2-methoxy-purine methyl ester.
    Acta Crystallogr.     C54, 659-661.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1998)
    Diethyl 3,7-hypoxanthyldiacetate.
    Acta Crystallogr.     C54, 114-116.
  • Walsh, A.J., Clark, G.C. and Fraser, W. (1997)
    A direct and efficient method for derivatisation of solid supports for oligonucleotide synthesis.
    Tetrahedron Lett.     38, 1651-1654.
  • Bradley, R.F., Schwalbe, C.H., Ross, K.C., Fraser, W. and Freeman, S., (1997)
    6-Nitrophthalide.
    Acta Crystallogr.     C53, 1626-1628.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1997)
    2,6-Diamino-9-(carboxymethyl)purine ethyl ester.
    Acta Crystallogr.     C53, 1624-1626.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1997)
    N    -(tert-Butoxycarbonyl(amino) acetonitrile.
    Acta Crystallogr.     C53, 959-961.
  • Wallis, M.P., Schwalbe, C.H. and Fraser, W. (1997)
    Synthesis and stability of oligonucleotide duplexes containing N4 aralkyl-substituted cytosine bases.
    Nucleosides & Nucleotides     16, 2053-2068.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1997)
    2,6-Diazido-9-(carboxymethyl)purine methyl ester.
    Acta Crystallogr.     C53, 608-610.
  • Routledge, A., Wallis, M.P., Ross, K.C. and Fraser, W. (1997)
    An efficient deprotection strategy for automated oligonucleotide synthesis using a novel silyl-linked solid support.
    In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 1995, ed. Epton, R., Mayflower, Worldwide, Kingswinford: 147-150.
  • Walsh, A.J., Ross, K.C., Routledge, A., Wallis, M.P. and Fraser, W. (1996)
    Solid phase synthesis of a mitozolomide-oligonucleotide conjugate using a novel silyl-linked solid support.
    Pharmaceutical Sciences     2, 33-38.
  • Worthington, V.L., Fraser, W. and Schwalbe, C.H. (1995)
    The N-7 regio-isomer of 2-chloro-2'-deoxyadenosine: synthesis, Ccystal structure, conformation and stability.
    Carbohydrate Res.     275, 275-284.
  • Routledge, A., Wallis, M.P., Ross, K.C. and Fraser, W. (1995)
    A new deprotection strategy for automated oligonucleotide synthesis using a novel silyl-linked solid support.
    Bioorg. Med. Chem. Lett.     5, 2059-2064.
  • Wallis, M.P., Spiers, I.D., Schwalbe, C.H. and Fraser, W. (1995)
    Direct synthesis, substitution, and structure of 1-(2'-deoxy-_-D-erythro-pentofuranosyl)-4-pentafluorophenyl-pyrimidin-2H-one.
    Tetrahedron Lett.     36, 3759-3763.
  • Chan, D.M.C., Schwalbe, C.H., Sood, G. and Fraser, W. (1995)
    9-(Carboxymethyl)-2,6-dichloropurine ethyl ester: an intermediate for peptidic nucleic acid synthesis.
    Acta Crystallogr.    , C51, 2383-2386.
  • Husbands, S., Fraser, W., Suckling, C.J., Wood, H.C.S. (1995)
    Latent inhibitors part 11. The synthesis of 5-spirocyclopropyl dihydroorotic acid.
    Tetrahedron     51, 865-870.
  • Fraser, W., Suckling, C.J., Wood, H.C.S. (1990)
    Latent inhibitors part 7. Inhibition of dihydro-orotate dehydrogenase by spirocyclopropano-barbiturates.
    J. Chem. Soc., Perkin Trans. 1     3137-3144.

Published Abstracts

  • Malik, S., Davis, M.L., Clayton, R., Cathcart, G.A., Ramsden, C.A., and Fraser, W. (2000)
    Pyridine-Stretched Nucleoside Regio-Isomers: Synthesis and Characterisation.
    J. Pharm. Pharmacol. (Suppl.)     52, 119.
  • Clayton, R., Davis, M.L., Cathcart, G.A., Ramsden C.A. and Fraser, W. (1999).
    Pyridine-stretched oligonuleotide (PSO) monomers.
    J. Pharm. Pharmacol. (Suppl.)     51, 202.
  • Howard, S., Rathbone, D.L., O'Carroll, B. and Fraser, W. (1999)
    Parallel matrix synthesis of modified cytosine and adenosine nucleosides.
    J. Pharm. Pharmacol. (Suppl.)     51, 201.
  • Walsh, A.J., Farrow, K.C. and Fraser, W. (1998)
    DNA targeting: Relationship between structure and triplex stability.
    Folia Pharmaceutica Universitatis Carolinae, (Suppl.)     23, 63-64.

Dr Bill Fraser / Aston University / last updated July 2009