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Dr Bill Fraser

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Lecturer in Medicinal Chemistry


UG Admissions Tutor - Pharmacy

Aston Pharmacy School
School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET
UK

email: w.fraser@aston.ac.uk
telephone: +44 (0) 121 204 3940

Member of the Medicines Research Unit
Member of the Pharmacy and Biology Teaching Programmes

Teaching Activity on the MPharm Programme

Spectroscopic analysis and biological chemistry (modules PH1405, PH2504 [module coordinator], PH3602 and PH3605.)

Career History

1991-date Lecturer in Medicinal Chemistry, Aston University
1989-91 Royal Society Post-doctoral Fellow, Eth, Zurich
1986-89 PhD, University of Strathclyde
1982-86 BSc Hons, Class I, Chemistry University of Strathclyde

Research Interests

  • Solid phase chemical synthesis
  • Antisense/antigene technology
  • Molecular recognition
  • Heterocyclic synthesis

Recent Publications

  • Crawford JA, Fraser W, Ramsden CA (2009) Preparation of 9-Substituted   Pyridine-Stretched Adenines and Hypoxanthine, Synthesis, 1271-1278  ISSN 0936-5214
  • Fraser W Oxatriazoles In Comprehensive Heterocyclic Chemistry III Katrizky AR, Ramsden CA, Scriven EFV, Taylor RJK Eds. Elsevier: Oxford 2008 Vol 6, pp 425-440
  • Fraser W 1,2,3-Oxadiazoles In Comprehensive Heterocyclic Chemistry III Katrizky AR, Ramsden CA, Scriven EFV, Taylor RJK Eds. Elsevier: Oxford 2008 Vol 5, pp 211-242
  • Walsh AJ, Davis ML, Fraser W (2006). Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate. Molecules 11: 486-495.
  • Fraser W Alkylboron and –Silicon Compounds In Comprehensive Organic Functional Group Transformations II Katrizky AR, Taylor RJK Eds. Elsevier: Oxford 2005 Vol 2 Chapter 2.10 pp 485-530.
  • Clayton, R., Davis, M.L., Fraser, W., Li, W., and Ramsden, C.A. (2002)
    Synthesis of Pyridine-stretched 2'-Deoxynucleosides
    Synlett.     1483-1486.
  • Walsh, A.J. and Fraser, W. (2001)
    Oligonucleotide Conjugates of the Base-Labile Anticancer Drug Temodal: SLCPG-Supported Solid Phase Synthesis.
    In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 1999, ed. Epton, R., Mayflower Worldwide, Kingswinford, Ch. 30, pp 137-140.
  • Walsh, A.J. and Fraser, W. (2001)
    Replacement of Adenine by Isoguanine in Triplex-Forming DNA Oligomers is Not Destabilising.
    In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 1999, ed. Epton, R., Mayflower Worldwide, Kingswinford, Ch. 100, pp 377-378.
  • Wallis, M.P., Mahmood, N. and Fraser, W. (1999)
    Synthesis and Anti-HIV activity of C4-modified pyrimidine nucleosides.
    Farmaco     54, 83-89.
  • Groebke, K., Hunziker, J., Fraser, W., Peng, L., Diederichsen, U., Zimmermann, K., Holzner, A., Leumann C. and A Eschenmoser (1998)
    Why pentose-and not hexose- nucleic acids? Purine-purine pairing in homo-DNA series: Guanine, isoguanine, 2,6-diaminopurine and xanthine.
    Helvetica Chimica Acta     81, 375-474.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1998)
    9-(Carboxymethyl)-6-chloropurine ethyl ester.
    Acta Crystallogr.     C54, 1907-1909.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1998)
    7-(Carboxymethyl)-6-chloropurine ethyl ester.
    Acta Crystallogr.     C54, 1316-1318.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1998)
    6-Amino-9-(carboxymethyl)-2-methoxy-purine methyl ester.
    Acta Crystallogr.     C54, 659-661.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1998)
    Diethyl 3,7-hypoxanthyldiacetate.
    Acta Crystallogr.     C54, 114-116.
  • Walsh, A.J., Clark, G.C. and Fraser, W. (1997)
    A direct and efficient method for derivatisation of solid supports for oligonucleotide synthesis.
    Tetrahedron Lett.     38, 1651-1654.
  • Bradley, R.F., Schwalbe, C.H., Ross, K.C., Fraser, W. and Freeman, S., (1997)
    6-Nitrophthalide.
    Acta Crystallogr.     C53, 1626-1628.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1997)
    2,6-Diamino-9-(carboxymethyl)purine ethyl ester.
    Acta Crystallogr.     C53, 1624-1626.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1997)
    N    -(tert-Butoxycarbonyl(amino) acetonitrile.
    Acta Crystallogr.     C53, 959-961.
  • Wallis, M.P., Schwalbe, C.H. and Fraser, W. (1997)
    Synthesis and stability of oligonucleotide duplexes containing N4 aralkyl-substituted cytosine bases.
    Nucleosides & Nucleotides     16, 2053-2068.
  • Sood, G., Schwalbe, C.H. and Fraser, W. (1997)
    2,6-Diazido-9-(carboxymethyl)purine methyl ester.
    Acta Crystallogr.     C53, 608-610.
  • Routledge, A., Wallis, M.P., Ross, K.C. and Fraser, W. (1997)
    An efficient deprotection strategy for automated oligonucleotide synthesis using a novel silyl-linked solid support.
    In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 1995, ed. Epton, R., Mayflower, Worldwide, Kingswinford: 147-150.
  • Walsh, A.J., Ross, K.C., Routledge, A., Wallis, M.P. and Fraser, W. (1996)
    Solid phase synthesis of a mitozolomide-oligonucleotide conjugate using a novel silyl-linked solid support.
    Pharmaceutical Sciences     2, 33-38.
  • Worthington, V.L., Fraser, W. and Schwalbe, C.H. (1995)
    The N-7 regio-isomer of 2-chloro-2'-deoxyadenosine: synthesis, Ccystal structure, conformation and stability.
    Carbohydrate Res.     275, 275-284.
  • Routledge, A., Wallis, M.P., Ross, K.C. and Fraser, W. (1995)
    A new deprotection strategy for automated oligonucleotide synthesis using a novel silyl-linked solid support.
    Bioorg. Med. Chem. Lett.     5, 2059-2064.
  • Wallis, M.P., Spiers, I.D., Schwalbe, C.H. and Fraser, W. (1995)
    Direct synthesis, substitution, and structure of 1-(2'-deoxy-_-D-erythro-pentofuranosyl)-4-pentafluorophenyl-pyrimidin-2H-one.
    Tetrahedron Lett.     36, 3759-3763.
  • Chan, D.M.C., Schwalbe, C.H., Sood, G. and Fraser, W. (1995)
    9-(Carboxymethyl)-2,6-dichloropurine ethyl ester: an intermediate for peptidic nucleic acid synthesis.
    Acta Crystallogr.    , C51, 2383-2386.
  • Husbands, S., Fraser, W., Suckling, C.J., Wood, H.C.S. (1995)
    Latent inhibitors part 11. The synthesis of 5-spirocyclopropyl dihydroorotic acid.
    Tetrahedron     51, 865-870.
  • Fraser, W., Suckling, C.J., Wood, H.C.S. (1990)
    Latent inhibitors part 7. Inhibition of dihydro-orotate dehydrogenase by spirocyclopropano-barbiturates.
    J. Chem. Soc., Perkin Trans. 1     3137-3144.

Published Abstracts

  • Malik, S., Davis, M.L., Clayton, R., Cathcart, G.A., Ramsden, C.A., and Fraser, W. (2000)
    Pyridine-Stretched Nucleoside Regio-Isomers: Synthesis and Characterisation.
    J. Pharm. Pharmacol. (Suppl.)     52, 119.
  • Clayton, R., Davis, M.L., Cathcart, G.A., Ramsden C.A. and Fraser, W. (1999).
    Pyridine-stretched oligonuleotide (PSO) monomers.
    J. Pharm. Pharmacol. (Suppl.)     51, 202.
  • Howard, S., Rathbone, D.L., O'Carroll, B. and Fraser, W. (1999)
    Parallel matrix synthesis of modified cytosine and adenosine nucleosides.
    J. Pharm. Pharmacol. (Suppl.)     51, 201.
  • Walsh, A.J., Farrow, K.C. and Fraser, W. (1998)
    DNA targeting: Relationship between structure and triplex stability.
    Folia Pharmaceutica Universitatis Carolinae, (Suppl.)     23, 63-64.