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Dr Eduard Badarau

Dr Eduard Badarau

Research Fellow (Marie Curie)

Qualifications & Education

  • PhD in Medicinal Chemistry, University of Orleans, France, 2009
  • M. Eng, University of Bacau, Romania, 2005
  • Chem. Eng, “Politehnica” University of Bucharest, Romania, 2003

Employment

  • 2011 – date: Research Fellow (Marie Curie), TRANSCOM project, Life & Health Sciences, Aston University, Birmingham, United Kingdom
  • 2009 – 2010: Research Fellow, NEUREDGE Project, GIGA Neurosciences & School of Pharmacy, University of Liege, Belgium

Research interests

  • Target-oriented design and synthesis of heterocyclic and peptidomimetic derivatives  
  • In silico design of biologically active agents (pharmacophores, dockings, QSAR, molecular dynamics, homology modeling)
  • GPCRs, ion channels, transglutaminases

Selected publications

  • “Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels”, E. Badarau, S. Dilly, F. Dufour, S. Poncin, V. Seutin, J.-F. Liégeois, Bioorganic & Medicinal Chemistry Letters, 2011, 21 (22), 6756 

  • “SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modelling”, E. Badarau, R. Bugno, F. Suzenet, A. J. Bojarski, A. Finaru and G. Guillaumet, Bioorganic & Medicinal Chemistry, 2010, 18, 1958

  •  “New Insights in the Homopiperazine-based 5-HT1A/5-HT7R ligands: Synthesis and biological evaluation”, E. Badarau, Aurelien Putey, Franck Suzenet, Benoit Joseph, Andrzej J. Bojarski, Adriana-Luminiţa Finaru and Gerald Guillaumet, Journal of Enzyme Inhibition and Medicinal Chemistry, 2010, 25 (3), 301

  • “Synthesis of 3-amino-8-azachromans and 3-amino-7-azabenzofurans via inverse electron demand Diels–Alder reaction“, E. Badarau, F. Suzenet, A. Finaru and G. Guillaumet, European Journal of Organic Chemistry, 2009, 21, 3619

  • “Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: Synthesis and biological evaluation”, E. Badarau, F. Suzenet, A. J. Bojarski, A. Finaru and G. Guillaumet, Bioorganic & Medicinal Chemistry Letters, 2009, 19 (6), 1600