Dr Defang Ouyang

Lecturer in Pharmaceutics

Aston University, Aston Triangle
Birmingham, B4 7ET, UK

• Room: MB357B
• E-mail: d.ouyang@aston.ac.uk
• Telephone: +44 (0) 121 204 4021

Qualifications & Education

• 2007 - 2010 PhD, School of Pharmacy, The University of Queensland, Australia (Supervisor: Dr. Harendra S. Parekh and Prof. Sean C. Smith)
• 2002 - 2005 MSc (Pharmacy), Shenyang Pharmaceutical University, China (Supervisor: Prof. Weisan Pan)
• 1996 - 2000 BSc (Pharmacy), Shenyang Pharmaceutical University, China
  

Employment

• 2011 - date Lecturer in Pharmaceutics, Aston University, UK
• 2005 - 2007 Research scientist, Shenzhen Main Luck Pharmaceutical Inc., China
• 2000 - 2002 Engineer, Tianjin Huajin Pharmaceutical Company, China
  

Teaching activity

• Pharmaceutics and drug delivery
  

Research interests

Computational pharmaceutics is to apply computer modelling technique on drug delivery to explore the mechanisms of drug delivery at the molecular level and then develop novel drug delivery systems:

• Cyclodextrin-drug complexes; 

• Solid dispersion; 

• siRNA-polymer complexes.
  

External Activities

Reviewer of <Int. J. Pharm.>, <J. Pharm. Pharmacol.>, <Drug Dev. Ind. Pharm.>, <BMC Biotechnology>, <Pharmaceutics> and <Biomacromolecules>; Reviewer of French National Research Agency (ANR); Guest editor of Special Issue "Gene Therapy" of <Pharmaceutics>; Member of editorial board of <American Journal of Polymer Science>; Member of The Academy of Pharmaceutical Sciences (UK) and The Controlled Release Society (CRS).

Selected publications

Papers

• Y. Perrie, R. K. Badhana, D.J. Kirby, D. Lowry, A. R. Mohammed and D. Ouyang, The impact of ageing on the barriers to drug delivery. Journal of Controlled Release (accepted);

• D. Ouyang, H.Zhang, H. Parekh and S.C. Smith, The Effect of pH on PAMAM Dendrimer-siRNA Complexation – Endosomal Considerations as Determined by Molecular Dynamics Simulation. Biophys. Chem., 2011, 158, 126–133;

• D. Ouyang, H.Zhang, H. Parekh and S.C. Smith, Structure and Dynamics of multiple polymers-siRNA Complexation by Molecular Dynamics Study. J. Phys. Chem. B., 2010, 114, 9231–9237
• D. Ouyang, H.Zhang, D.Herten, H. Parekh and S.C. Smith, Structure, Dynamics and Energetics of siRNA-Cationic Vector Complexation: A Molecular Dynamics Study. J. Phys. Chem. B., 2010, 114, 9220–9230.
• D. Ouyang, H.Zhang, D.Herten, H. Parekh and S.C. Smith, “Flexibility of Short-Strand RNA in Aqueous Solution as Revealed by Molecular Dynamics Simulation: Are A-RNA and A’-RNA Distinct Conformational Structures?” Aust. J. Chem., 2009, 62, 1054-1061.
• D. Ouyang, N. Shah, H. Zhang, S.C. Smith and H. Parekh, “Reducible Disulphide-Based Non-Viral Gene Delivery Systems”, Mini-Rev. Med. Chem., 2009, 9, 1242-1250.

Oral presentation

• The Effect of pH on PAMAM Dendrimer-siRNA Complexation – Endosomal Considerations as Determined by Molecular Dynamics Simulation. 7th Annual Conference of the ARC Centre of Excellence for Functional Nanomaterials (ARCCFN). (Gold Coast, Queensland, Australia, November 25-26, 2010).
• Structure, Dynamics and Energetics of siRNA-polymer Complexation: A Molecular Dynamics Study. 6th Annual Conference of the ARC Centre of Excellence for Functional Nanomaterials (ARCCFN). (Coffs Harbor, New South Wales, Australia, November 9-11, 2009).