Michael D. Coleman, B.Sc., Ph.D., D.Sc., F.H.E.A

Professor of Toxicology

Aston Pharmacy School
School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET
UK

email: m.d.coleman@ aston.ac.uk
telephone: +44 (0) 121 204 3916
fax: +44 (0) 121 359 0733

Mechanisms of Toxicity Group Tyrant

Member of the Molecular Biosciences Research Group
Member of research strand 'Development of novel drugs, formulations and tissues to support healthy ageing' - Aston Research Centre for Healthy Ageing
Member of the Pharmacy and Biology Teaching Programmes

Career History

• 2007: Elected Fellow of the Royal Society of Medicine.
• 2003-2006: Senior Lecturer in Toxicology Aston University
• 2005: Doctor of Science (D.Sc.) awarded, Aston University
• 1991-2003: Lecturer in Toxicology, Aston University
• 1989-91: Wellcome Fellow in Toxicology, University of Liverpool
• 1986-88: Resident Research Associate (National Research Council), Walter Reed Army Institute of Research, USA
• 1982-85: Ph.D., University of Liverpool
• 1979-82: BSc Hons, Pharmacology (Class I), University of Liverpool

Current funding and Personnel

• Humane Research Trust Fellows: Dr. Elizabeth Woehrling and Dr. David Nagel

• Antidote Direct Research Associate: Dr. Cristina Jimenez-Gonzalez

• BBSRC Research Fellow to be appointed

Research Interests

• Design of in vitro neurotoxicity assay systems using human cells and tissues

• Design of functional models of human neuronal and astrocytic activity

• Toxicological testing and development of anti-tuberculosis drugs

• Toxicological mechanisms of sulphone adverse reactions

• Mechanisms of methaemoglobin formation

• Molecular mechanisms of diabetic complications

Editorships

• Associate Editor (with Dr. Louis Radulovic) for Volume VI (Drug Metabolism and Interactions in Humans, Clinical aspects) of a forthcoming six volume 'Encyclopaedia of Drug Metabolism and Drug Interactions' to be published by Wiley International (2011).

• Associate Editor for Environmental Toxicology and Pharmacology (2006-the present)

• Guest Editor for the Special Editions on ‘Antioxidants: Unlocking their potential (ETAP 10, No 4 September 2001)

• Progress in the development of in vitro human-based Alternatives to animal models (ETAP 21 No 2 February 2006)

Publications:

2007-the present

• Woehrling EK, Hill EJ, Torr EE, Coleman MD,
  Single-cell ELISA and flow cytometry as methods for highlighting potential neuronal and astrocytic toxicant specificity. Neurotoxicity Research (currently being revised)

• Woehrling EK, Hill EJ, Coleman MD (2010)
  Evaluation of the Importance of Astrocytes When Screening for Acute Toxicity in Neuronal Cell Systems
  Neurotoxicity Research 17 103-113

• Holden LJ, Coleman MD (2008)
  Further preliminary assessment of three human glioma cell lines as models of human astrocytic toxicity in vitro
  Environmental Toxicology and Pharmacology 26 290-296

• Hill EJ, Woehrling EK, Prince M, Coleman MD. (2008)
  Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing Toxicology 249 243-250

• M.D. Coleman, T.R. Zilz, H.R. Griffiths E. A. Woehrling.(2008)
  A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y.
  Basic and Clinical Pharmacology and Toxicology 102 25-29

• Veggi LM, Pretto L, Ochoa EJ, Catania VA, Luquita MG, Taborda DR, Pozzi EJS, Ikushiro S, Coleman MD, Roma MG Mottino AD (2008)
  Dapsone induces oxidative stress and impairs antioxidant defenses.
  Life Sci. 83 155-163

• C.A. Brown, J.Y. Brown and M.D. Coleman.(2007)
  How drug metabolism influences treatment outcomes.
  Expert Opinion in Drug Metabolism and Toxicology 3 913-915

• E. A. Woehrling, E.J. Hill and M.D. Coleman. (2007)
  Development of a neurotoxicity test-system using human post-mitotic astrocytic and neuronal cell lines in co-culture. Toxicology in vitro Special Issue 21 1241-1246

• L.J Holden and M.D. Coleman. (2007)
  Assessment of the astrogliotic responses of three human astrocytoma cell lines to ethanol, trimethyltin chloride, and acrylamide.
  Toxicology 241 75-83

• M.D. Coleman  (2007)
  Conjugative and Transport Mechanisms.
  Syva Drug Monitor 4.11 84-87

• M.D. Coleman (2007)
  Common drug interactions.
  Syva Drug Monitor 4.12

• T.R. Zilz, H.R. Griffiths and M.D. Coleman. (2007)
  Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH.
  Toxicology 231 210-214

• M.D. Coleman,G.R. Rimmer and G.R.M.M .Haenen. (2007)
  Effects of lipoic acid and dihydrolipoic acid on total erythrocytic thiols under conditions of restricted glucose in vitro.
  Basic and Clinical Pharmacology and Toxicology 100 139-144

Prof Mike Coleman/ Aston University / last updated April 2010