Professor of Toxicology
Aston Pharmacy School
School of Life & Health Sciences
Birmingham B4 7ET
email: m.d.coleman@ aston.ac.uk
telephone: +44 (0) 121 204 3916
fax: +44 (0) 121 204 4187
Teaching Activity on the MPharm Programme
PH3605: Drug Metabolism and biotransformation
PH4704: Essential communication skills, scientific writing and presentation, project management
PH4705: Science of the Future: CNS in vitro
Mechanisms of Toxicity Group Leader
Member of the Chronic Diseases Research Group (Biomedical Sciences)
Member of research strand 'Development of novel drugs, formulations and tissues to support healthy ageing' - Aston Research Centre for Healthy Ageing
Member of the Pharmacy and Biology Teaching Programmes
Current funding and Personnel
Humane Research Trust Fellows: Dr. Elizabeth Woehrling and Dr. David Nagel
Antidote Direct Research Associate: Dr. Cristina Jimenez-Gonzalez
BBSRC Research Fellow to be appointed
Design of in vitro neurotoxicity assay systems using human cells and tissues
Design of functional models of human neuronal and astrocytic activity
Toxicological testing and development of anti-tuberculosis drugs
Toxicological mechanisms of sulphone adverse reactions
Mechanisms of methaemoglobin formation
Molecular mechanisms of diabetic complications
Associate Editor (with Dr. Louis Radulovic) for Volume VI (Drug Metabolism and Interactions in Humans, Clinical aspects) of a forthcoming six volume 'Encyclopaedia of Drug Metabolism and Drug Interactions' to be published by Wiley International (2011).
Associate Editor for Environmental Toxicology and Pharmacology (2006-the present)
Guest Editor for the Special Editions on ‘Antioxidants: Unlocking their potential (ETAP 10, No 4 September 2001)
Progress in the development of in vitro human-based Alternatives to animal models (ETAP 21 No 2 February 2006)
Woehrling EK, Hill EJ, Torr EE, Coleman MD,
Single-cell ELISA and flow cytometry as methods for highlighting potential neuronal and astrocytic toxicant specificity. Neurotoxicity Research (currently being revised)
Woehrling EK, Hill EJ, Coleman MD (2010)
Evaluation of the Importance of Astrocytes When Screening for Acute Toxicity in Neuronal Cell Systems
Neurotoxicity Research 17 103-113
Holden LJ, Coleman MD (2008)
Further preliminary assessment of three human glioma cell lines as models of human astrocytic toxicity in vitro
Environmental Toxicology and Pharmacology 26 290-296
Hill EJ, Woehrling EK, Prince M, Coleman MD. (2008)
Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing Toxicology 249 243-250
M.D. Coleman, T.R. Zilz, H.R. Griffiths E. A. Woehrling.(2008)
A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y.
Basic and Clinical Pharmacology and Toxicology 102 25-29
Veggi LM, Pretto L, Ochoa EJ, Catania VA, Luquita MG, Taborda DR, Pozzi EJS, Ikushiro S, Coleman MD, Roma MG Mottino AD (2008)
Dapsone induces oxidative stress and impairs antioxidant defenses.
Life Sci. 83 155-163
C.A. Brown, J.Y. Brown and M.D. Coleman.(2007)
How drug metabolism influences treatment outcomes.
Expert Opinion in Drug Metabolism and Toxicology 3 913-915
E. A. Woehrling, E.J. Hill and M.D. Coleman. (2007)
Development of a neurotoxicity test-system using human post-mitotic astrocytic and neuronal cell lines in co-culture. Toxicology in vitro Special Issue 21 1241-1246
L.J Holden and M.D. Coleman. (2007)
Assessment of the astrogliotic responses of three human astrocytoma cell lines to ethanol, trimethyltin chloride, and acrylamide.
Toxicology 241 75-83
M.D. Coleman (2007)
Conjugative and Transport Mechanisms.
Syva Drug Monitor 4.11 84-87
M.D. Coleman (2007)
Common drug interactions.
Syva Drug Monitor 4.12
T.R. Zilz, H.R. Griffiths and M.D. Coleman. (2007)
Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH.
Toxicology 231 210-214
M.D. Coleman,G.R. Rimmer and G.R.M.M .Haenen. (2007)
Effects of lipoic acid and dihydrolipoic acid on total erythrocytic thiols under conditions of restricted glucose in vitro.
Basic and Clinical Pharmacology and Toxicology 100 139-144