Professor Andrew Pitt

School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET
UK

Email: a.r.pitt@aston.ac.uk

Tel: +44 (0)121 204 3005

Member of Medicines Research Unit  

Teaching Activity on the MPharm Programme

PH3602: Antimicrobial agents and anticancer agents
PH3605: Medicinal chemistry – drugs from natural products and modern approaches to target discovery

Research interests

Former Director of the Sir Henry Wellcome Functional Genomics Facility at the University of Glasgow, Andrew joined Aston in January 2011. His previous post headed a state of the art facility for the generation of data for systems biology, from high throughput gene sequencing and transcriptomics to proteomics and metabolomics. Andrew's research involved the development of new technologies and methodologies for the generation of in depth genomic, proteomic and metabolomic data, with a specific focus on generating detailed functional analysis and spatial and temporal data for systems biology, as well as working with small samples and clinical materials for systems medicine. Coupling increased depth of analysis with higher throughput methods, and integrating data seamlessly across different data types provided a fundamental platform for systems analysis.

Research funding

2009 – 2012 Engineering and Physical Sciences Research Council. The Molecular Nose

2008 – 2015 Engineering and Physical Sciences Research Council. A Doctoral Training Centre for cell and proteomic technologies

2007 – 2011 Scottish Funding Council. Biomarkers for Battling Chromic Disease

2005 – 2011 Biotechnology and Biological Sciences Research Council. The RASOR Interdisciplinary Research Collaboration in Proteomic Technologies.

Collaborations
 

Walter Kolch (Beatson Institute)
Harald Mischak (Mosaiques Diagnostics)
Michael Barrett (University of Glasgow)
Richard Burchmore (University of Glasgow)
Alan Crozier (University of Glasgow)
Anna Dominiczak (University of Glasgow)
Pat Langridge-Smith (University of Edinburgh)
Anthony Walton (University of Edinburgh)
Nick Morrice (University of Dundee)
Paul Crocker (University of Dundee)
Ted Hupp (University of Edinburgh)
Duncan Graham (University of Strathclyde)
Adam West (University of Glasgow)
Lee Cronin (University of Glasgow)
Jon Cooper (University of Glasgow)
David Goodlett (University of Washington)

Key publications

Burgess, K.E.V., Lainson, A., Imrie, L., Fraser-Pitt, D., Yaga, R., Smith, D.G.E., Swart, R., Pitt, A.R. and Inglis, N.F.
Performance of Five Different Electrospray Ionisation Sources in Conjunction with Rapid Monolithic Column Liquid Chromatography and Fast MS/MS Scanning.
Proteomics, accepted for publication.

Zimmerli, L. U., Schiffer, E., Zurbig, P., Good, D. M., Kellmann, M., Mouls, L., Pitt, A. R., Coon, J. J., Schmieder, R. E., Peter, K., Mischak, H., Kolch, W., Delles, C., and Dominiczak, A. F. (2008)
 Urinary proteomic biomarkers in coronary artery disease
Molecular Cellular Proteomics 7, 2, 290-298.

Goodwin, R. J. A., Dungworth, J. C., Cobb, S. R., and Pitt, A. R. (2008)
Time-dependent evolution of tissue markers by MALDI-MS imaging Proteomics 8, 18, 3801-3808.

Von Kriegsheim, A., Pitt, A. R., Grindlay, G. J., Kolch, W., and Dhillon, A. S. (2006 )
Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5 Nature Cell Biology 8, 9, 1011-1016.

Spickett, C. M., Pitt, A. R., Morrice, N., and Kolch, W. (2006)
Proteomic analysis of phosphorylation, oxidation and nitrosylation in signal transduction
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 1764, 12, 1823-1841.

Breitling, R., Pitt, A. R., and Barrett, M. P. (2006 )
Precision mapping of the metabolome
Trends In Biotechnology 24, 12, 543-548.