Dr Afzal R Mohammed

Qualifications & education

• PhD, Aston University (Supervisor, Prof Yvonne Perrie) (2004)
• MSc Sheffield Hallam University (2001)
• Bachelor of Pharmacy (1999)

Employment

• 2011- date : Senior Lecturer in Pharmaceutics, Aston University
• 2007- 2011: Lecturer in Pharmaceutics, Aston University
• 2004-2007: Research Fellow, Aston University (PI, Prof Yvonne Perrie)

External activities

Committee memberships

• Member of Academy of Pharmaceutical Sciences
• Member of Controlled Release Society
• Member of United Kingdom and Ireland Controlled Release Society

Oral presentations

•   “Novel formulations of Rapidly Disintegrating Tablets” presented at symposium on Rapidly Disintegrating Tablets 14^th February (2011), Leciester, UK.

• "Introduction to orally disintegrating tablets" presented at NHS Pharmaceutical Quality Assurance Service  Annual Symposium 27th – 28th September (2010) Birmingham.

• “Novel zero saccharide fast disintegrating tablets” presented at the British Pharmaceutical Conference. Sept 9-11 (2009): Manchester: U.K 

•  “Solubilisation of poorly soluble drugs: engineering nanosystems” NHS Pharmaceutical Quality Assurance Service  Annual Symposium 6th – 7th October (2008) Manchester.

•  “How to avoid cold chain in pharmaceutical product development” presented at SMI conference on cold chain distribution Feb (2008) London.

• “Product development of sub unit TB vaccines” presented at the EU 6th framework meeting Jan 31-3Feb (2006): Switzerland.

• “The development of liposomal sub unit TB vaccine: bench to clinic” presented at the British Pharmaceutical Conference. Sept 4-6 (2006): Manchester: U.K.

• Teaching activity

• Member of the Medicines Research Unit
• Member of the Pharmacy and Biology Teaching Programmes
• Module co-ordinator: PH2CT1 and PH2CT2
• Year Tutor: First year, third year Pharmacy and MSc (Drug Delivery and Pharmaceutical Sciences).

Research interest

• Engineering solid solutions for the delivery of bioactive small and large molecules using first principles of freeze drying

• Solubility improvement of BCS class II drugs

• Understanding the genomic signature of drug delivery systems using micro arrays

• Paediatric Formulation development and characterisation

Recent research funding

My research group gratefully acknowledge the support of: Advantage West Midlands, Aston University, Apex Healthcare Ltd, BBSRC, Colorcon Ltd, EPSRC, Pharmaspec Ltd and Pharmatrust Ltd.

Selected publications 

Rhys J. Jones , Ali Rajabi-Siahboomi , Marina Levina , Yvonne Perrie  and Afzal R. Mohammed (2011) The Influence of Formulation and Manufacturing Process Parameters on the Characteristics of Lyophilized Orally Disintegrating Tablets. Pharmaceutics, 3, 440-457.

AlHusban, F., Perrie, Y., Mohammed, A.R (2011) Formulation of Multiparticulate Systems as Lyophilised Orally Disintegrating Tablets. European Journal of Pharmaceutics and Biopharmaceutics (Accepted).

Sheraz Khan, Hannah Batchelor, Peter Hanson, Yvonne Perrie, and Afzal R Mohammed (2011) Physicochemical characterisation, drug polymer dissolution and in vitro evaluation of Phenacetin and Phenylbutazone solid dispersions with polyethylene glycol 8000. Journal of Pharmaceutical Sciences, 100, 10, 4281-4294.

Hesham Tawfeek, Sayed Khidr, Eman Samy, Sayed Ahmed, Mark Murphy, Afzal Mohammed, Anjum Shabir, Gillian Hutcheon, Imran Saleem (2011). Poly(glycerol adipate-co-ω-pentadecalactone) spray dried microparticles as sustained release carriers for pulmonary delivery. Pharmaceutical Research 28,9, 2086- 2097.

Anjumn Shabir, Farhan AlHusban, Yvonne Perrie and Afzal R Mohammed (2011). Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles. Journal of Basic and Clinical Pharmacy,2,2,71-82..

Sheraz Khan, Amr ElShaer , Ayesha S Rahman, Peter Hanson, Yvonne Perrie, and Afzal R Mohammed(2011).  Systems biology approach to study permeability of paracetamol and its solid dispersion.International Journal of Pharmaceutics, 417, 1-2, 272-279..

Sheraz Khan, Amr ElShaer, Ayesha S Rahman, Peter Hanson, Yvonne Perrie and Afzal R Mohammed (2011). Genomic evaluation during permeability of indomethacin and its solid dispersion.  Journal of Drug Targeting 19, 8, 615-23.

Behfar Moghaddam, M. Habib Ali, Jitinder Wilkhu, Daniel J. Kirby, Afzal R. Mohammed, Qinguo Zheng and Yvonne Perrie (2011). The application of monolayer studies in the understanding of liposomal formulations.  International Journal of Pharmaceutics 417(1-2):235-44.

Sagida Bibi, Randip Kaur, Malou Henriksen-Lacey, Sarah E. McNeil, Jitinder Wilkhu, Dennis Christensen, Else Marie Agger, Peter Andersen, Afzal Mohammed and Yvonne Perrie (2011). Microscopy Imaging of bilayer vesicles: From coverslips to environmental SEM. International Journal of Pharmaceutics 417(1-2):138-50.

Amr ElShaer, Sheraz Khan, Dhaya Perumal, Peter Hanson and Afzal R Mohammed (2011). Use of amino acids as counter ions improves the solubility of the BCS II model drug, indomethacin.Current Drug Delivery 8(4):363-72.

Farhan AlHusban, Amr ElShaer, Rhys Jones and Afzal R Mohammed (2010). Recent patents and trends in formulation of orally disintegrating tablet.  Journal of Recent patents in formulation and drug delivery; 4, 3, 178-197.

Anjumn Shabir and Afzal R Mohammed (2010). Exploring the use of cyclodextrins as carriers in paediatric formulations.  The British Journal of Clinical Pharmacy; 2,9, 275-278.

Afzal R Mohammed, Vincent W. Bramwell, Daniel J. Kirby, Srah E.McNeil and Yvonne Perrie (2010). Increased potential of a cationic liposome-based delivery system: Enhancing stability and sustained immunological activity in preclinical development. European Journal of Pharmaceutics and Biopharmaceutics; 76,3, 404- 412.

M Habib Ali, Daniel J Kirby, Afzal.R. Mohammed^d , and Y. Perrie (2010) Solubilisation of drugs within liposomal bilayers – alternatives to cholesterol as a membrane stabilising agent. Journal of Pharmacy and Pharmacology; 62, 11, 1646-1655.

AlHusban, F., Perrie, Y., Mohammed, A.R (2010) Formulation and characterisation of lyophilised rapid disintegrating tablets using amino acids as matrix forming agents. European Journal of Pharmaceutics and Biopharmaceutics; 75, 2, 254-262.

AlHusban FA, ElShaer A, Kansara J, Smith A, Grover L, Perrie Y, Mohammed A(2010) - Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination. Pharmaceutics; 2 (1): 1-17.

AlHusban, F., Mohammed, A (2010) Novel zero saccharide orally disintegrating tablets.  Industrial Pharmacy, 26, 16-18.

Alhusban FA, Perrie Y, Mohammed A (2010) Preparation, optimisation and characterisation of lyophilised rapid disintegrating tablets based on gelatin and saccharide. Current Drug Delivery; 7: 65-75.

Rahul Chandrasekhar, Zahra Hassan, Farhan AlHusban, Alan M Smith, Afzal R Mohammed (2009) The role of formulation excipients in the development of lyophilized fast disintegrating tablets. European Journal of Pharmaceutics and Biopharmaceutics 72(1):119-29.

Hofmann, MP, Mohammed AR, Perrie Y, Gbureck U, Barralet JE.(2009) High Strength brushite bone cement with controlled drug releasing capabilities.  Acta Biomaterialia 5, 1, 43-49.

Yvonne Perrie, Afzal R Mohammed, Daniel Kirby, Sarah Mcneil and Vincent W Bramwell and (2008) Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens. International Journal of Pharmaceutics 364-2, 272-280.

Yvonne Perrie, Daniel Kirby, Vincent W Bramwell and Afzal R Mohammed (2007). Recent developments in particulate-based vaccines.  Recent Patents on Drug Delivery and Formulation 1: 2: 1-13.

Mohammed, A. R, Coombes, AGA, Fitzgerald, M and Perrie,Y (2007).  Amino acids as potential cryoprotectants for Liposomal delivery systems.  European Journal of Pharmaceutical Sciences; 30; 406-413.

Afzal R. Mohammed, Allan.G.A. Coombes, Vincent W Bramwell, and Yvonne Perrie (2006).  Lyophilisation and sterilisation of liposomal vaccines to produce stabile and sterile products.  Methods; 40: 1; 30-38.

Yvonne Perrie, Afzal U. R. Mohammed, Anil Vangala, and Sarah E. McNeil (2006) Environmental Scanning Electron Microscopy offers real-time morphological analysis of liposomes andniosomes. Journal of Liposome Research 17 (1); 27-37.

Mohammed, A.R and Perrie, Y (2005) Liposome solutions for sparingly soluble drugs. Drug Delivery Companies Report; 9-11.

A.R. Mohammed, A.G.A Coombes, Bock. N, M. Fitzgerald and Y. Perrie (2004).  Liposome formulation of poorly water soluble drugs: optimization of drug loading and ESEM analysis of stability.  International Journal of Pharmaceutics 285; 1-2; 23-34.

My research group has published over 65 peer reviewed abstracts at various national and international conferences.

Patents

1. ACH/P108627GB00 - 16^th November 2009

2. SCB/HMC/P111450GB00 - 9^th April 2010

Book chapters   

Christensen D, Korsholm K, Wood KJ, Mohammed AM, Bramwell VW, Agger EM and Perrie Y (2008) Liposomes as adjuvant systems for parenteral delivery of vaccines.  Delivery Technologies forBiopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines.

Perrie Y, Ali H, Kirby DJ, Mohammed AU, McNeil SE, Vangala A(2010) Environmental Scanning Electron Microscope Imaging of Vesicle Systems. Methods in Molecular Biology 606:319-31.

Afzal R. Mohammed, Amr M. ElShaer, Rhys J. Jones, Sheraz Khan, Craig A. Russell (2011) Drug Bioavailability and Gene Profiling: Challenges and Opportunities for Pharmaceutics and Personalised Medicine. Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery and Therapy.