Project Titles for Biomedical Sciences

Molecular & Cell Biology    

• Protein oxidation in stress and inflammatory disease
  Supervisors: Dr C Spickett and Prof Andrew Pitt

 Communicable Diseases

• Design, synthesis and screening of potential inhibitors of the enzyme New Delhi Metallo-b -lactamase  
  Supervisor:  Dr Dan Rathbone
  Associate Supervisors:  Dr Tony Worthington & Dr Anthony Hilton
  Available for non-Home/EU students only - excellent applicants may apply for an international/overseas scholarship of £6,000 per year deducted from international/overseas fees   

• Aminopyridinone stabilization of triple helical DNA
  Supervisor: Dr William Fraser   

• Fluorescent Sensors for Triplex DNA
  Supervisor: Dr William Fraser 

• Pro-drug Inhibitors of Clostridium difficile
  Supervisor: Dr William Fraser 

• Size-Expanded DNA Structures
  Supervisor: Dr William Fraser 

• Targeting Dihydro-orotate Dehydrogenase in C.difficile
  Supervisors: Dr William Fraser  & Dr Ann Vernallis

• Design and synthesis of transglutaminase inhibitors as potential therapeutic agents for neurodegenerative disease
  Supervisors: Dr Dan Rathbone and Prof Martin Griffin

• Chemical and computational modelling of Cytochrome P450 CYP2D6
  Supervisor:Dr Dan Rathbone

• Tissue Fibrosis and Neurodegeneration
  Supervisors: Dr Dan Rathbone, Prof Martin Griffin and Prof Peter Lambert
  
  
• Design and synthesis of inhibitors of mycobacterial chorismate mutase
  Dr Dan Rathbone and Prof Mike Coleman

• Synthesis and evaluation of EGCG analogues as breast cancer preventive agents 
  Supervisor: Dr Qinguo Zheng

Chronic Diseases 

• Design and synthesis of novel antagonists at family B G-protein coupled receptors
  Supervisors: Dr David Poyner & Dr Dan Rathbone 
  

•  Are elevated levels of glycated and oxidised proteins predictive of type 2 diabetes mellitus in older adults?
  Supervisors: Prof Helen Griffiths & Dr Sri Bellary 

• Biomaterials for Application in Soft and Hard Tissue Repair
  Supervisors: Dr Russell Collighan and Prof Martin Griffin  

• Dysregulation of tissue Transglutaminase(TG2) contributes to protein aggregation and age-related neurodegeneration 
  Supervisors: Prof Martin Griffin and Dr Russell Collighan
  

• Enzymatically cross-linked collagen to facilitate dermal repair of diabetic ulcers
  Supervisors: Prof Martin Griffin and  Dr Russell Collighan

• Design and synthesis of small organic molecules as venom antidotes 
  Supervisor: Dr Eric Lattmann