Project titles for Biomedical Sciences

Molecular & Cell Biology    

• New Project Title To Be Uploaded
  Supervisors: Dr C Spickett and Prof Andrew Pitt 

• The effect of lipid environment on MRP1 function
  Supervisor: Dr Alice Rothnie
  

 Communicable Diseases

• Periodontitis - understanding the relationship between pathogens, neutrophils, macrophages and chronic inflammation 
  Supervisor:  Dr Andrew Devitt

• Aminopyridinone stabilization of triple helical DNA
  Supervisor: Dr William Fraser   

• Fluorescent Sensors for Triplex DNA
  Supervisor: Dr William Fraser 

• Pro-drug Inhibitors of Clostridium difficile
  Supervisor: Dr William Fraser 

• Size-Expanded DNA Structures
  Supervisor: Dr William Fraser 

• Targeting Dihydro-orotate Dehydrogenase in C.difficile
  Supervisors: Dr William Fraser  & Dr Ann Vernallis

• Design and synthesis of transglutaminase inhibitors as potential therapeutic agents for neurodegenerative disease
  Supervisors: Dr Dan Rathbone and Prof Martin Griffin

• Design, synthesis and screening of potential inhibitors of the enzyme New Delhi Metallo-ß -lactamase
  Supervisor:Dr Dan Rathbone

• Tissue Fibrosis and Neurodegeneration
  Supervisors: Dr Dan Rathbone, Prof Martin Griffin and Prof Peter Lambert
  
  
• Design and synthesis of inhibitors of mycobacterial chorismate mutase
  Dr Dan Rathbone and Prof Mike Coleman

• Synthesis and evaluation of EGCG analogues as breast cancer preventive agents 
  Supervisor: Dr Qinguo Zheng

Chronic Diseases 

• Design and synthesis of novel antagonists at family B G-protein coupled receptors
  Supervisors: Dr David Poyner & Dr Dan Rathbone 
  

•  Are elevated levels of glycated and oxidised proteins predictive of type 2 diabetes mellitus in older adults?
  Supervisors: Prof Helen Griffiths & Dr Sri Bellary 

• Biomaterials for Application in Soft and Hard Tissue Repair
  Supervisors: Dr Russell Collighan & Prof Martin Griffin  

• Dysregulation of tissue Transglutaminase(TG2) contributes to protein aggregation and age-related neurodegeneration 
  Supervisors: Prof Martin Griffin & Dr Russell Collighan

• Enzymatically cross-linked collagen to facilitate dermal repair of diabetic ulcers
  Supervisors: Prof Martin Griffin & Dr Russell Collighan

• The role of tissue Transglutaminase in regulating cancer progression and its use as a potential prognostic biomarker
  Supervisors: Prof Martin Griffin & Dr James Brown & Dr Vivian Wang

• Design and synthesis of small organic molecules as venom antidotes 
  Supervisor: Dr Eric Lattmann